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We present 7 HIV-infected patients with a unique,subacute,progressive polyradiculopathy.All had AIDS,sacral sensory loss,acute urinary retention,and progression to flaccid paraparesis in days to weeks. Cytomegalovirus was cultured from spinal fluid of 4 patients,and postmortem examination on the 1st 5 patients disclosed an inflammatory polyradiculopathy with cytomegalic inclusions.The inclusion-bearing cells were immunocytochemically positive for cytomegalovirus.Two patients who received early anti-cytomegalovirus treatment with ganciclovir improved. Thus,early recognition and treatment with ganciclovir may be effective in this otherwise fatal condition. |
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